vitamin d3 analogue mc903 Search Results


psorcutan beta  (Anwendung GmbH)
90
Anwendung GmbH psorcutan beta
Psorcutan Beta, supplied by Anwendung GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/vitamin+d3+analogue+mc903/psorcutan+beta/10__1055_slash_s___2005___870184-53-0-23
Average 90 stars, based on 1 article reviews
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taclonex scalp topical suspension  (Warner Chilcott)
90
Warner Chilcott taclonex scalp topical suspension
Taclonex Scalp Topical Suspension, supplied by Warner Chilcott, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/vitamin+d3+analogue+mc903/taclonex+scalp+topical+suspension/pmc02683609-14-22-5
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mc903  (Tocris)
95
Tocris mc903
Figure 4. Compound 6 inhibits persistent itch behavior. A–C) Efficacy of compound 6 in the DNFB model of persistent itch. A) Experimental diagram showing the induction of spontaneous itch behavior by topical application of 2,4-dinitrofluorobenzene (DNFB) to the nape of the neck (twice 14 days apart), i.p. drug delivery 105 min after the second DNFB application, and videotaping 15 min thereafter. Compound 6 significantly reduced the number of scratching bouts (B) and the number of head shakes (C) as compared to vehicle. Data are presented as mean ± SEM (n = 6–7). p = 0.004, unpaired Student’s t-test (B); p = 0.0014, unpaired Student’s t-test (C). D–F) Efficacy of compound 6 in the <t>MC903</t> model of persistent itch. D) Experimental diagram showing the induction of spontaneous scratching by topical application of MC903 to the nape of the neck (once daily over 7 days), i.p. drug delivery at day 8, and videotaping 15 min thereafter. In comparison to the vehicle, compound 6 significantly reduced the number of scratching bouts (E) and the number of head shakes (F). In E, box-and-whisker plots represent maximum and minimum values, and the box shows the first, second (median), and third quartile values. All other data are presented as mean ± SEM (n = 12). p = 0.0319, Mann–Whitney test (E); p = 0.0008, unpaired Student’s t-test (F);. *p < 0.05, **p < 0.01, ***p < 0.001. Schemes in A and D were created with BioRender.com.
Mc903, supplied by Tocris, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/vitamin+d3+analogue+mc903/Calcipotriol/pm38350720-501-5-9
Average 95 stars, based on 1 article reviews
mc903 - by Bioz Stars, 2026-11
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calcipotriol  (Anwendung GmbH)
90
Anwendung GmbH calcipotriol
Figure 4. Compound 6 inhibits persistent itch behavior. A–C) Efficacy of compound 6 in the DNFB model of persistent itch. A) Experimental diagram showing the induction of spontaneous itch behavior by topical application of 2,4-dinitrofluorobenzene (DNFB) to the nape of the neck (twice 14 days apart), i.p. drug delivery 105 min after the second DNFB application, and videotaping 15 min thereafter. Compound 6 significantly reduced the number of scratching bouts (B) and the number of head shakes (C) as compared to vehicle. Data are presented as mean ± SEM (n = 6–7). p = 0.004, unpaired Student’s t-test (B); p = 0.0014, unpaired Student’s t-test (C). D–F) Efficacy of compound 6 in the <t>MC903</t> model of persistent itch. D) Experimental diagram showing the induction of spontaneous scratching by topical application of MC903 to the nape of the neck (once daily over 7 days), i.p. drug delivery at day 8, and videotaping 15 min thereafter. In comparison to the vehicle, compound 6 significantly reduced the number of scratching bouts (E) and the number of head shakes (F). In E, box-and-whisker plots represent maximum and minimum values, and the box shows the first, second (median), and third quartile values. All other data are presented as mean ± SEM (n = 12). p = 0.0319, Mann–Whitney test (E); p = 0.0008, unpaired Student’s t-test (F);. *p < 0.05, **p < 0.01, ***p < 0.001. Schemes in A and D were created with BioRender.com.
Calcipotriol, supplied by Anwendung GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/vitamin+d3+analogue+mc903/calcipotriol/pm21627770-838-0-6
Average 90 stars, based on 1 article reviews
calcipotriol - by Bioz Stars, 2026-11
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calcipotriol  (DWK Life Sciences)
90
DWK Life Sciences calcipotriol
Figure 4. Compound 6 inhibits persistent itch behavior. A–C) Efficacy of compound 6 in the DNFB model of persistent itch. A) Experimental diagram showing the induction of spontaneous itch behavior by topical application of 2,4-dinitrofluorobenzene (DNFB) to the nape of the neck (twice 14 days apart), i.p. drug delivery 105 min after the second DNFB application, and videotaping 15 min thereafter. Compound 6 significantly reduced the number of scratching bouts (B) and the number of head shakes (C) as compared to vehicle. Data are presented as mean ± SEM (n = 6–7). p = 0.004, unpaired Student’s t-test (B); p = 0.0014, unpaired Student’s t-test (C). D–F) Efficacy of compound 6 in the <t>MC903</t> model of persistent itch. D) Experimental diagram showing the induction of spontaneous scratching by topical application of MC903 to the nape of the neck (once daily over 7 days), i.p. drug delivery at day 8, and videotaping 15 min thereafter. In comparison to the vehicle, compound 6 significantly reduced the number of scratching bouts (E) and the number of head shakes (F). In E, box-and-whisker plots represent maximum and minimum values, and the box shows the first, second (median), and third quartile values. All other data are presented as mean ± SEM (n = 12). p = 0.0319, Mann–Whitney test (E); p = 0.0008, unpaired Student’s t-test (F);. *p < 0.05, **p < 0.01, ***p < 0.001. Schemes in A and D were created with BioRender.com.
Calcipotriol, supplied by DWK Life Sciences, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/vitamin+d3+analogue+mc903/calcipotriol/pmc06717763-118-18-25
Average 90 stars, based on 1 article reviews
calcipotriol - by Bioz Stars, 2026-11
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mc903 (calcipotriol)  (Adooq Bioscience LLC)
90
Adooq Bioscience LLC mc903 (calcipotriol)
Figure 4. Compound 6 inhibits persistent itch behavior. A–C) Efficacy of compound 6 in the DNFB model of persistent itch. A) Experimental diagram showing the induction of spontaneous itch behavior by topical application of 2,4-dinitrofluorobenzene (DNFB) to the nape of the neck (twice 14 days apart), i.p. drug delivery 105 min after the second DNFB application, and videotaping 15 min thereafter. Compound 6 significantly reduced the number of scratching bouts (B) and the number of head shakes (C) as compared to vehicle. Data are presented as mean ± SEM (n = 6–7). p = 0.004, unpaired Student’s t-test (B); p = 0.0014, unpaired Student’s t-test (C). D–F) Efficacy of compound 6 in the <t>MC903</t> model of persistent itch. D) Experimental diagram showing the induction of spontaneous scratching by topical application of MC903 to the nape of the neck (once daily over 7 days), i.p. drug delivery at day 8, and videotaping 15 min thereafter. In comparison to the vehicle, compound 6 significantly reduced the number of scratching bouts (E) and the number of head shakes (F). In E, box-and-whisker plots represent maximum and minimum values, and the box shows the first, second (median), and third quartile values. All other data are presented as mean ± SEM (n = 12). p = 0.0319, Mann–Whitney test (E); p = 0.0008, unpaired Student’s t-test (F);. *p < 0.05, **p < 0.01, ***p < 0.001. Schemes in A and D were created with BioRender.com.
Mc903 (Calcipotriol), supplied by Adooq Bioscience LLC, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/vitamin+d3+analogue+mc903/mc903++calcipotriol+/pm30878670-105-0-2
Average 90 stars, based on 1 article reviews
mc903 (calcipotriol) - by Bioz Stars, 2026-11
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calcipotriol  (MedChemExpress)
95
MedChemExpress calcipotriol
Figure 4. Compound 6 inhibits persistent itch behavior. A–C) Efficacy of compound 6 in the DNFB model of persistent itch. A) Experimental diagram showing the induction of spontaneous itch behavior by topical application of 2,4-dinitrofluorobenzene (DNFB) to the nape of the neck (twice 14 days apart), i.p. drug delivery 105 min after the second DNFB application, and videotaping 15 min thereafter. Compound 6 significantly reduced the number of scratching bouts (B) and the number of head shakes (C) as compared to vehicle. Data are presented as mean ± SEM (n = 6–7). p = 0.004, unpaired Student’s t-test (B); p = 0.0014, unpaired Student’s t-test (C). D–F) Efficacy of compound 6 in the <t>MC903</t> model of persistent itch. D) Experimental diagram showing the induction of spontaneous scratching by topical application of MC903 to the nape of the neck (once daily over 7 days), i.p. drug delivery at day 8, and videotaping 15 min thereafter. In comparison to the vehicle, compound 6 significantly reduced the number of scratching bouts (E) and the number of head shakes (F). In E, box-and-whisker plots represent maximum and minimum values, and the box shows the first, second (median), and third quartile values. All other data are presented as mean ± SEM (n = 12). p = 0.0319, Mann–Whitney test (E); p = 0.0008, unpaired Student’s t-test (F);. *p < 0.05, **p < 0.01, ***p < 0.001. Schemes in A and D were created with BioRender.com.
Calcipotriol, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/vitamin+d3+analogue+mc903/Calcipotriol/pm41591834-200-13-11
Average 95 stars, based on 1 article reviews
calcipotriol - by Bioz Stars, 2026-11
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calcipotriol g−1 plus betamethasone 0·5 g−1 gel (as the dipropionate) dovobet® gel  (LEO Pharma)
90
LEO Pharma calcipotriol g−1 plus betamethasone 0·5 g−1 gel (as the dipropionate) dovobet® gel
Figure 4. Compound 6 inhibits persistent itch behavior. A–C) Efficacy of compound 6 in the DNFB model of persistent itch. A) Experimental diagram showing the induction of spontaneous itch behavior by topical application of 2,4-dinitrofluorobenzene (DNFB) to the nape of the neck (twice 14 days apart), i.p. drug delivery 105 min after the second DNFB application, and videotaping 15 min thereafter. Compound 6 significantly reduced the number of scratching bouts (B) and the number of head shakes (C) as compared to vehicle. Data are presented as mean ± SEM (n = 6–7). p = 0.004, unpaired Student’s t-test (B); p = 0.0014, unpaired Student’s t-test (C). D–F) Efficacy of compound 6 in the <t>MC903</t> model of persistent itch. D) Experimental diagram showing the induction of spontaneous scratching by topical application of MC903 to the nape of the neck (once daily over 7 days), i.p. drug delivery at day 8, and videotaping 15 min thereafter. In comparison to the vehicle, compound 6 significantly reduced the number of scratching bouts (E) and the number of head shakes (F). In E, box-and-whisker plots represent maximum and minimum values, and the box shows the first, second (median), and third quartile values. All other data are presented as mean ± SEM (n = 12). p = 0.0319, Mann–Whitney test (E); p = 0.0008, unpaired Student’s t-test (F);. *p < 0.05, **p < 0.01, ***p < 0.001. Schemes in A and D were created with BioRender.com.
Calcipotriol G−1 Plus Betamethasone 0·5 G−1 Gel (As The Dipropionate) Dovobet® Gel, supplied by LEO Pharma, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/vitamin+d3+analogue+mc903/calcipotriol+g+1+plus+betamethasone+0%C2%B75+g+1+gel++as+the+dipropionate++dovobet++gel/pmc04298245-71-6-28
Average 90 stars, based on 1 article reviews
calcipotriol g−1 plus betamethasone 0·5 g−1 gel (as the dipropionate) dovobet® gel - by Bioz Stars, 2026-11
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calcipotriol scalp solution  (LEO Pharma)
90
LEO Pharma calcipotriol scalp solution
Figure 4. Compound 6 inhibits persistent itch behavior. A–C) Efficacy of compound 6 in the DNFB model of persistent itch. A) Experimental diagram showing the induction of spontaneous itch behavior by topical application of 2,4-dinitrofluorobenzene (DNFB) to the nape of the neck (twice 14 days apart), i.p. drug delivery 105 min after the second DNFB application, and videotaping 15 min thereafter. Compound 6 significantly reduced the number of scratching bouts (B) and the number of head shakes (C) as compared to vehicle. Data are presented as mean ± SEM (n = 6–7). p = 0.004, unpaired Student’s t-test (B); p = 0.0014, unpaired Student’s t-test (C). D–F) Efficacy of compound 6 in the <t>MC903</t> model of persistent itch. D) Experimental diagram showing the induction of spontaneous scratching by topical application of MC903 to the nape of the neck (once daily over 7 days), i.p. drug delivery at day 8, and videotaping 15 min thereafter. In comparison to the vehicle, compound 6 significantly reduced the number of scratching bouts (E) and the number of head shakes (F). In E, box-and-whisker plots represent maximum and minimum values, and the box shows the first, second (median), and third quartile values. All other data are presented as mean ± SEM (n = 12). p = 0.0319, Mann–Whitney test (E); p = 0.0008, unpaired Student’s t-test (F);. *p < 0.05, **p < 0.01, ***p < 0.001. Schemes in A and D were created with BioRender.com.
Calcipotriol Scalp Solution, supplied by LEO Pharma, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/vitamin+d3+analogue+mc903/calcipotriol+scalp+solution/pmc09246247-32-8-12
Average 90 stars, based on 1 article reviews
calcipotriol scalp solution - by Bioz Stars, 2026-11
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calcipotriene cream 0.005  (Prasco Laboratories)
90
Prasco Laboratories calcipotriene cream 0.005
Figure 4. Compound 6 inhibits persistent itch behavior. A–C) Efficacy of compound 6 in the DNFB model of persistent itch. A) Experimental diagram showing the induction of spontaneous itch behavior by topical application of 2,4-dinitrofluorobenzene (DNFB) to the nape of the neck (twice 14 days apart), i.p. drug delivery 105 min after the second DNFB application, and videotaping 15 min thereafter. Compound 6 significantly reduced the number of scratching bouts (B) and the number of head shakes (C) as compared to vehicle. Data are presented as mean ± SEM (n = 6–7). p = 0.004, unpaired Student’s t-test (B); p = 0.0014, unpaired Student’s t-test (C). D–F) Efficacy of compound 6 in the <t>MC903</t> model of persistent itch. D) Experimental diagram showing the induction of spontaneous scratching by topical application of MC903 to the nape of the neck (once daily over 7 days), i.p. drug delivery at day 8, and videotaping 15 min thereafter. In comparison to the vehicle, compound 6 significantly reduced the number of scratching bouts (E) and the number of head shakes (F). In E, box-and-whisker plots represent maximum and minimum values, and the box shows the first, second (median), and third quartile values. All other data are presented as mean ± SEM (n = 12). p = 0.0319, Mann–Whitney test (E); p = 0.0008, unpaired Student’s t-test (F);. *p < 0.05, **p < 0.01, ***p < 0.001. Schemes in A and D were created with BioRender.com.
Calcipotriene Cream 0.005, supplied by Prasco Laboratories, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/vitamin+d3+analogue+mc903/calcipotriene+cream+0+005/pmc07703669-411-8-11
Average 90 stars, based on 1 article reviews
calcipotriene cream 0.005 - by Bioz Stars, 2026-11
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vitamin d3 analogue mc903  (LEO Pharma)
90
LEO Pharma vitamin d3 analogue mc903
Figure 4. Compound 6 inhibits persistent itch behavior. A–C) Efficacy of compound 6 in the DNFB model of persistent itch. A) Experimental diagram showing the induction of spontaneous itch behavior by topical application of 2,4-dinitrofluorobenzene (DNFB) to the nape of the neck (twice 14 days apart), i.p. drug delivery 105 min after the second DNFB application, and videotaping 15 min thereafter. Compound 6 significantly reduced the number of scratching bouts (B) and the number of head shakes (C) as compared to vehicle. Data are presented as mean ± SEM (n = 6–7). p = 0.004, unpaired Student’s t-test (B); p = 0.0014, unpaired Student’s t-test (C). D–F) Efficacy of compound 6 in the <t>MC903</t> model of persistent itch. D) Experimental diagram showing the induction of spontaneous scratching by topical application of MC903 to the nape of the neck (once daily over 7 days), i.p. drug delivery at day 8, and videotaping 15 min thereafter. In comparison to the vehicle, compound 6 significantly reduced the number of scratching bouts (E) and the number of head shakes (F). In E, box-and-whisker plots represent maximum and minimum values, and the box shows the first, second (median), and third quartile values. All other data are presented as mean ± SEM (n = 12). p = 0.0319, Mann–Whitney test (E); p = 0.0008, unpaired Student’s t-test (F);. *p < 0.05, **p < 0.01, ***p < 0.001. Schemes in A and D were created with BioRender.com.
Vitamin D3 Analogue Mc903, supplied by LEO Pharma, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/vitamin+d3+analogue+mc903/mc903/pm18650845-55-45-50
Average 90 stars, based on 1 article reviews
vitamin d3 analogue mc903 - by Bioz Stars, 2026-11
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calcipotriene 0.005% foam  (MATHESON)
90
MATHESON calcipotriene 0.005% foam
Figure 4. Compound 6 inhibits persistent itch behavior. A–C) Efficacy of compound 6 in the DNFB model of persistent itch. A) Experimental diagram showing the induction of spontaneous itch behavior by topical application of 2,4-dinitrofluorobenzene (DNFB) to the nape of the neck (twice 14 days apart), i.p. drug delivery 105 min after the second DNFB application, and videotaping 15 min thereafter. Compound 6 significantly reduced the number of scratching bouts (B) and the number of head shakes (C) as compared to vehicle. Data are presented as mean ± SEM (n = 6–7). p = 0.004, unpaired Student’s t-test (B); p = 0.0014, unpaired Student’s t-test (C). D–F) Efficacy of compound 6 in the <t>MC903</t> model of persistent itch. D) Experimental diagram showing the induction of spontaneous scratching by topical application of MC903 to the nape of the neck (once daily over 7 days), i.p. drug delivery at day 8, and videotaping 15 min thereafter. In comparison to the vehicle, compound 6 significantly reduced the number of scratching bouts (E) and the number of head shakes (F). In E, box-and-whisker plots represent maximum and minimum values, and the box shows the first, second (median), and third quartile values. All other data are presented as mean ± SEM (n = 12). p = 0.0319, Mann–Whitney test (E); p = 0.0008, unpaired Student’s t-test (F);. *p < 0.05, **p < 0.01, ***p < 0.001. Schemes in A and D were created with BioRender.com.
Calcipotriene 0.005% Foam, supplied by MATHESON, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/vitamin+d3+analogue+mc903/calcipotriene+0+005++foam/pm32738429-892-12-2
Average 90 stars, based on 1 article reviews
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Image Search Results


Figure 4. Compound 6 inhibits persistent itch behavior. A–C) Efficacy of compound 6 in the DNFB model of persistent itch. A) Experimental diagram showing the induction of spontaneous itch behavior by topical application of 2,4-dinitrofluorobenzene (DNFB) to the nape of the neck (twice 14 days apart), i.p. drug delivery 105 min after the second DNFB application, and videotaping 15 min thereafter. Compound 6 significantly reduced the number of scratching bouts (B) and the number of head shakes (C) as compared to vehicle. Data are presented as mean ± SEM (n = 6–7). p = 0.004, unpaired Student’s t-test (B); p = 0.0014, unpaired Student’s t-test (C). D–F) Efficacy of compound 6 in the MC903 model of persistent itch. D) Experimental diagram showing the induction of spontaneous scratching by topical application of MC903 to the nape of the neck (once daily over 7 days), i.p. drug delivery at day 8, and videotaping 15 min thereafter. In comparison to the vehicle, compound 6 significantly reduced the number of scratching bouts (E) and the number of head shakes (F). In E, box-and-whisker plots represent maximum and minimum values, and the box shows the first, second (median), and third quartile values. All other data are presented as mean ± SEM (n = 12). p = 0.0319, Mann–Whitney test (E); p = 0.0008, unpaired Student’s t-test (F);. *p < 0.05, **p < 0.01, ***p < 0.001. Schemes in A and D were created with BioRender.com.

Journal: Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Article Title: Discovery of a Small Molecule Activator of Slack (Kcnt1) Potassium Channels That Significantly Reduces Scratching in Mouse Models of Histamine-Independent and Chronic Itch.

doi: 10.1002/advs.202307237

Figure Lengend Snippet: Figure 4. Compound 6 inhibits persistent itch behavior. A–C) Efficacy of compound 6 in the DNFB model of persistent itch. A) Experimental diagram showing the induction of spontaneous itch behavior by topical application of 2,4-dinitrofluorobenzene (DNFB) to the nape of the neck (twice 14 days apart), i.p. drug delivery 105 min after the second DNFB application, and videotaping 15 min thereafter. Compound 6 significantly reduced the number of scratching bouts (B) and the number of head shakes (C) as compared to vehicle. Data are presented as mean ± SEM (n = 6–7). p = 0.004, unpaired Student’s t-test (B); p = 0.0014, unpaired Student’s t-test (C). D–F) Efficacy of compound 6 in the MC903 model of persistent itch. D) Experimental diagram showing the induction of spontaneous scratching by topical application of MC903 to the nape of the neck (once daily over 7 days), i.p. drug delivery at day 8, and videotaping 15 min thereafter. In comparison to the vehicle, compound 6 significantly reduced the number of scratching bouts (E) and the number of head shakes (F). In E, box-and-whisker plots represent maximum and minimum values, and the box shows the first, second (median), and third quartile values. All other data are presented as mean ± SEM (n = 12). p = 0.0319, Mann–Whitney test (E); p = 0.0008, unpaired Student’s t-test (F);. *p < 0.05, **p < 0.01, ***p < 0.001. Schemes in A and D were created with BioRender.com.

Article Snippet: Five days later, 20 μL MC903 (0.2 mm; Calcipotriol, Tocris) solved in absolute ethanol was applied to the skin at the back of the neck under brief anesthesia for 7 consecutive days.

Techniques: Comparison, Whisker Assay, MANN-WHITNEY